The Evidence Is In – Complimentary and Alternative Medicine

 

What is CAM?  What does it mean to be evidence based?  These, and many other questions were discussed at an MLA Continuing Education course I attended at the MCMLA/SDLA meeting in October.   The course was Consumer Health: An Evidence Based Approach to Complementary & Alternative Medicine, taught by Stephanie Weldon, NN/LM MCR Consumer Health Liaison, Univ. of Colorado Health Sciences Library.

 

In her course description she included these facts.  “In 1997, the total visits to Complementary and Alternative Medicine (CAM) providers (629M) exceeded total visits to all primary care physicians (386M). Total out of pocket expenditures for CAM therapies were conservatively estimated at $27B. (JAMA 1998; 280:1569-75). The statistics cited suggest that your patrons may be interested in CAM therapies. This session will provide you with an evidenced based approach to evaluating CAM literature. Information on herbal resources and their efficacy will be discussed. We will also look at the literature and resources which will help us answer our patron's questions.   Come prepared for a lively discussion on CAM resources and methods for their evaluation.”    All these goals were met, and more.

 

Her course content is posted at http://nnlm.gov/mcr/consumer_health/cam/. Many links to reputable evidence based resources can be found through out the link indicated above.   We worked through the following agenda.  In the half-day course we were able to briefly cover each topic.

 

History of CAM in the U.S

Librarians Must Fill the Void

Categorization of Therapies

Review the Evidence

Databases and Web Sites

Collection Development

 

What is complementary and alternative medicine?

Complementary and alternative medicine, as defined by NCCAM (National Center for complementary and Alternative Medicine), http://nccam.nci.nih.gov/is a group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine.   While some scientific evidence exists regarding some CAM therapies, for most there are key questions that are yet to be answered through well-designed scientific studies--questions such as whether they are safe and whether they work for the diseases or medical conditions for which they are used.   The list of what is considered to be CAM changes continually, as those therapies that are proven to be safe and effective become adopted into conventional health care and as new approaches to health care emerge.

 

Are complementary medicine and alternative medicine different?

Again, NACAM presents the following distinctions.

 

·         Complementary medicine is used together with conventional medicine. An example of a complementary therapy is using aromatherapy to help lessen a patient's discomfort following surgery.

 

·         Alternative medicine is used in place of conventional medicine. An example of an alternative therapy is using a special diet to treat cancer instead of undergoing surgery, radiation, or chemotherapy that has been recommended by a conventional doctor.

 

Interesting Facts in the History of Alternative Medicine

·         Study from 1900 to present: shows CAM usage declined in 1940s and 50s with a trend in increased use since the 50s. Most CAM therapies are used to prevent future illness or maintain health.

 

·         Leading physician in the 18th century, Benjamin Rush, believed that blood  letting and purging were examples of scientific medicine. Alternative medicine usage was high during this period.

 

·         In ancient China the doctor is paid as long as the patient is healthy. The Doctor stopped getting paid when the patient became sick.

 

·         Many prescription drugs are “anti” they stop things from happening: Anticonvulsants Antidepressants, Antihistamines.  Alternative medicine seeks to be more pro active or positive.

 

·         Claims against chiropractors, massage therapists, and acupuncturists occur less frequently  then claims against medical doctors.

 

 

 

 

 

 


NCCAM:  Categorization of Therapies

 

The MD Anderson Cancer Center gives a thorough review of these therapies

1. Alternative Medical Systems:

Examples

·         Western: homeopathic medicine and naturopathic medicine.

·         Non-western: Chinese medicine and Ayurveda.

2. Mind-Body Interventions:

·         Some techniques that were considered CAM in the past have become mainstream (for example, patient support groups and cognitive-behavioral therapy).

·         Other mind-body techniques are still considered CAM, including meditation, prayer, mental healing, and therapies that use creative outlets such as art, music, or dance

3. Biologically Based Therapies...

Use substances found in nature, such as herbs, foods, and vitamins.   Some examples include dietary supplements, herbal products, and the scientifically unproven therapies (for example, using shark cartilage to treat cancer).

4. Manipulative and Body-Based Methods...

Are based on manipulation and/or movement of one or more parts of the body. Some examples include chiropractic or osteopathic manipulation, and massage.

5. Energy Therapies:

·         Biofield therapies - Examples include qi gong, Reiki, and Therapeutic Touch. Bioenergetics

·         Bioelectromagnetic-based therapies - electromagnetic fields, such as pulsed fields, magnetic fields, or alternating current or direct current fields.

 

 


Review of Evidence

 

Many therapies introduced before the 1960’s do not meet the criteria of evidenced based medicine (EBM) -- Most CAM therapies were introduced way before 1960

 

EBM – well designed randomized controlled clinical trials. Since the 1960’s all drugs approved by the FDA have met this standard.

 

Warfarin, aspirin and heparin were introduced before the randomized clinical trial. Warfarin is still not evidenced based - but remains a conventional therapy for heart disease.

 

If introduced in mainstream western society, though not evidenced based, the treatment is more likely to be accepted.

 

Western medicine must sort through therapies to find which should undergo RCT. If it passes criteria it should be integrated into the physicians treatment possibilities.

 

Selected Consensus Reports, Clinical Trials and Reviews Suggesting that CAM Therapies May Be Effective

David Eisenberg, Harvard Medical School, addresses these issues in an article linked here.    Links to a series of abstracts on these topics is listed here.  Full text is available in some cases.

 

 

 

Acupuncture

Is acupuncture effective in the treatment of fibromyalgia?

Acupuncture for Nausea and Dental Pain

Acupuncture for Post-operative Nausea

Acupuncture for Recurrent Headaches

Moxibustion for Breech Presentation

Allergies

Homeopathy for Allergic Rhinitis

Alzheimers

Gingko for the Treatment of Alzheimer's Type Dementia

A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia

Anxiety and Depression

Kava Kava for Anxiety

St. John's wort for the Treatment of Depression

St. John's wort vs. Imipramine vs. Placebo

Arthritis

Glucosamine and Chondroitin for Osteoarthritis

Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis

Cancer

Psychosocial Support Groups for Cancer

Coronary Heart Disease

Lifestyle Changes for Coronary Heat Disease

Changes in myocardial perfusion abnormalities by positron emission tomography after long-term, intense risk factor modification

Distant Healing and Spirituality

The efficacy of "distant healing": a systematic review of randomized trials

Efficacy of distant healing--a proposal for a four-armed randomized study (EUHEALS).

Intercessory Prayer

Hypercholesterolemia

Garlic for Hypercholesterolemia

Irritable Bowel Syndrome

Chinese Herbs for the Treatment of Irritable Bowel Syndrome

Pain and Balance Disorders

Chiropractic for Acute Low Back Pain

Spinal manipulation for low back pain. An updated systematic review of randomized clinical trials.

Osteopathic Manipulation for Low Back Pain

Massage for Low-Back Pain

Mind/Body Techniques for Pain, Insomnia

Tai Chi for Balance Disorders

Effects of tai chi exercise on pain, balance, muscle strength

PreMenstrual Syndrome

Agnus Castus Extract for Premenstrual Syndrome

Prostatic Hyperplasia

Saw Palmetto for the Treatment of Benign Prostatic Hyperplasia

Vertigo

Homeopathy for Vertigo

 

 

Selected Clinical Trials Suggesting That CAM Therapies May Lack Efficacy

 

Acupuncture for Peripheral Neuropathy

Acupuncture for Tinnitus

Chiropractic for Infantile Colic

Chiropractic vs. Physical Therapy vs. Education for Low Back Pain

Group Psychosocial Support for Metastatic Breast Cancer

Hair Analysis of Trace Minerals

     Hydroxycitric Acid for Obesity

 

Selected Articles Describing Significant Drug-Herb Interactions and/or Toxicity

 

Case Studies Involving the Most Commonly Used Medicinal Plants

Adverse Reactions Between St. John's wort and Prescription Drugs

Open-label Study Showing St. John's wort Decreases Indinavir Concentrations

Association of a Chinese Herb (Aristolochia fangchi) with Renal Failure and Urothelial Carcinoma

Letter to Lancet Editor regarding St. John's Wort Induced Heart Transplant Rejections

Summary of Ephedra's toxicity and Herbal medicines and perioperative care


 

 


Complementary and Alternative Medical Databases

 

Free

AGRICOLA - A bibliographic database of citations to the agricultural literature created by the U.S. National Agricultural Library and its cooperators.

 

The Combined Health Information Database (CHID) - CHID lists a wealth of health promotion and education materials and program descriptions that are not indexed elsewhere. CHID is updated four times a year. January, April, July, and October.

 

Database of Abstracts of Reviews of Effectiveness (DARE)The University of York.
The Center for Reviews and Dissemination was established in January 1994 to provide the National Health Service with important information on the effectiveness of treatments and the delivery and organization of health care.

 

Patient Information for Natural Therapies (The German, Patienteninformation fur Naturheilkunde) A searchable database, much of it in English, providing information on holistic medicine and a network linking research institutions and organizations worldwide. There are over 5,000 bibliographic entries and 1,000 addresses.

 

CAM on PubMed

 

ClinicalTrials.gov A database of ongoing and closed clinical trials developed and maintained by the U.S. National Institutes of Health

 

Cochrane Library Abstracts of Systematic Reviews A searchable database of the most up to date Cochrane Systematic Reviews. Includes reviews of CAM therapies

 

Cochrane Consumer Network The Collaboration is an international non-profit organization that aims to help people make informed decisions about health care, by reviewing and promoting the best available evidence on the effects of interventions and treatments.

 

HerbMed A searchable database which provides hyper linked access to the scientific data underlying the use of herbs for health. It is an evidence-based information resource for professionals, researchers, and general public.

 

HOM-INFORM The British Homeopathic Library indexes homeopathic literature in this free database. A database of literature references to homeopathy, with key terms and some abstracts. (Search on Clinical Trials)

 

The International Bibliographic Information on Dietary Supplements (IBIDS)

A database of published, international, scientific literature on dietary supplements, including vitamins, minerals, and botanicals.

 

MEDLINEplus is the National Library of Medicine's web site for consumer health information in English and Spanish. Content is provided for health topics, interactive health tutorials, drug information, current health news, dictionaries, directories, organizations, libraries, and databases.

 

Native American Ethnobotany - A database of plants used as drugs, food, fibers, dyes by native American people

 

Natural Pharmacist contains detailed information on more than 200 herbs and supplements, more than 100 different conditions and the conventional and natural treatments used to treat them, plus drug-herb and drug-supplement interactions for more than 75 drug categories

The University of Hawaii has a version you can access.

 

Poisonous Plant Database is a set of working files of scientific information about the animal and human toxicology of vascular plants of the world. The initial files were created in 1994, and are updated periodically.

 

Fee-Based

 

We have the following databases available through subscription.

 

Alt HealthWatch A full text database of journal articles from 140 periodicals, 24 peer-reviewed publications included: EBSCO.

 

Health Source: Consumer Edition provides full text articles, pamphlets, and book chapters on nutrition, exercise, medical self-care, drugs, alcohol, and more. Information provided in this consumer health database should not be viewed as a means of self-diagnosis or a substitute for professional medical advice.

·         Clinical Reference Systems provides over 7,000 reports, in every-day language, describing symptoms, treatments, risks, and after-effects of a vast array of medical topics and conditions. Spanish records have been added. It is part of Health Source: Consumer Edition.

 

Others databases are available, as well.    Consult http://nnlm.gov/mcr/consumer_health/cam/database.php for a list of these.

 

 

Virtually everyone in the United States is taking notice

Spending in Alternative Medicine - Out of pocket expenditures doubled from
1990 – 1997 -- $14b to $28b

 

Herbal medicine out of pocket payments $5.1b in 1997 with 12.1% of the adult US population using herbal medicines.

 

1999 - U.S. Pharmaceutical industry launches herbal products line -- $10b industry, 25% growth per year


 

The presenter reminds us the course was in no way a compilation of all of the complementary and alternative medicine resources that are available. Instead, it is an attempt to provide a look at evidence based and peer reviewed alternative medicine resources.

 

I, immediately, utilized this newly-found knowledge to update our Complementary and Alternative CAM resources on our redesigned web site  http://www.methodistcollege.edu/library/chsinternetresrcs/alternmedicine.htm.

Stephanie’s list is included, as a gateway, for it’s comprehensive coverage of this important topic.

 

comments and questions?
contact Angela Arner, Coordinator
Consumer Health Library Services,
John Moritz Library
Nebraska Methodist College
354-4611 or aarner@methodistcollege.edu

 

 


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